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| Class | Examples | Indications | Onset | Key Considerations | |-------|----------|-------------|-------|--------------------| | SSRIs | Fluoxetine, sertraline | Generalized anxiety, compulsive disorders, separation anxiety | 4-8 weeks | First-line for chronic anxiety. Side effects: GI upset, lethargy, reduced appetite. | | Tricyclic antidepressants | Clomipramine | Separation anxiety, compulsive disorders | 3-4 weeks | Similar to SSRIs; anticholinergic effects (dry mouth, urine retention). | | Benzodiazepines | Alprazolam, diazepam | Noise phobia, situational anxiety | 30-60 min | Risk of disinhibition aggression (paradoxical effect). Schedule IV controlled substance. | | Azapirones | Buspirone | Generalized anxiety (cats especially) | 2-3 weeks | No sedation, no dependency. Less effective for panic. | | Alpha-2 agonists | Dexmedetomidine (gel, oral) | Noise aversion | 1-2 hours | Causes sedation; use with caution in cardiac disease. | | Monoamine oxidase inhibitors | Selegiline | Cognitive dysfunction syndrome | 4-6 weeks | Also may improve learning. | In veterinary science, an increasing number of practitioners
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